It's all in the planning if you want smooth sailing on a trip with babies and toddlers.
If you are going to a hotel or resort, check with the resort before you go to see what kind of equipment and supplies they might have that will make your trip easier. Many have supplies to baby proof your hotel room as well as cribs, toys,bed rails, changing tables, potties, high chairs, and even strollers. The less you have to carry on the plane or in the car, the easier your trip will be.
Make sure you bring more diapers and food than you think you could possibly need on the plane or in the car. Travel delays are simply a routine part of travel and you need to be prepared!
If you're flying, don't check your stroller. You will most likely need it to get to your gate. You can check it as you board. You will have to fold your stroller or baby carrier and put it on the conveyor belt at security, so be ready for that before you even get in line.
As you approach the security line, be ready to make the process less stressful. Have your coats folded and in your carry on if it will fit. Wear shoes you can slip off easily. There's nothing more stressful than holding up traffic as you attempt to corral all your items and hang on to your baby in line. So be as ready as possible before you get in line.
And don't forget to back your child's favorite blanket or stuffed animal - it can help make a foreign crib or bed seem much more homey!